Isocyanic acid 3-pyridyl ester - Names and Identifiers
Isocyanic acid 3-pyridyl ester - Physico-chemical Properties
Molecular Formula | C6H4N2O
|
Molar Mass | 120.11 |
Density | 1.12 |
Boling Point | 182℃ |
Flash Point | 64℃ |
pKa | 3.75±0.10(Predicted) |
Storage Condition | Room Temprature |
Isocyanic acid 3-pyridyl ester - Introduction
3-ISOCYANATOPYRIDINE, chemical formula C7H4N2O2, is a white crystalline solid at room temperature. The following is a description of the nature, use, preparation and safety information of 3-ISOCYANATOPYRIDINE:
Nature:
1. Appearance: white crystalline solid;
2. Melting Point: 189-192 ℃;
3. Solubility: soluble in chloroform, alcohol, dimethyl ether and acetic acid and other organic solvents, almost insoluble in water;
4. Chemical properties: 3-ISOCYANATOPYRIDINE is a weak acid with nucleophilic addition reaction activity. It can undergo condensation reactions with compounds containing active hydrogen atoms and can prepare compounds related to isocyanates.
Use:
1. As a synthetic chemical intermediate, it can be used to synthesize compounds such as drugs, dyes, pesticides and polymer materials;
2. In organic synthesis, it can be used to synthesize substituted pyridine, imidazole and other compounds;
3. As an extractant, it can be used for the extraction of metal ions.
Method:
3-ISOCYANATOPYRIDINE is generally prepared by reacting 2-aminopyridine with phosgene. The specific steps are as follows:
1. Dissolve 2-aminopyridine in an organic solvent, and add chloroform or dichloromethane as a solvent;
2. Add carbonyl chloride Dropwise to the solution and keep the reaction temperature at low temperature;
3. After the reaction, the 3-ISOCYANATOPYRIDINE product can be obtained by filtration, crystallization or distillation purification.
Safety Information:
1. 3-isocyyanatopyridine is irritating. Contact with skin and eyes may cause irritation. Direct contact should be avoided;
2. In the process of use, should pay attention to protective measures, wear protective gloves, glasses and masks and other personal protective equipment;
3. Storage should be sealed and stored in a cool and dry place, away from fire and oxidant and other dangerous substances;
4. When operating and handling 3-ISOCYANATOPYRIDINE, correct laboratory operating practices should be followed to avoid unsafe situations.
Last Update:2024-04-09 02:00:42